Thyroid ophthalmopathy is currently is recognized as the most common cause of proptosis (protrusion of the globe) in adults (see the first image below). Other clinical features include upper and/or lower eyelid retraction (see the second image below), restrictive myopathy causing diplopia (double vision), compressive optic neuropathy, and exposure keratopathy. Although most patients are clinically hyperthyroid, signs of thyroid ophthalmopathy can be present regardless of thyroid function.
Severe proptosis and eyelid retraction from thyroid-related orbitopathy. This patient also had optic nerve dysfunction from thyroid-related orbitopathy.